Distinguished University Professor; Robert S. and Sylvia K. Reitman Family Foundation Chair of Cardiovascular Innovation; Professor of Medicine and of Biochemistry; President and co-Founder, Harrington Discovery Institute; Founding Director, Institute for Transformative Molecular Medicine Case Western Reserve University; University Hospitals Health System, Cleveland, OH USA

Often hailed as the ‘father’ of all gasotransmitters, nitric oxide (NO) laid much of the groundwork upon which the field of H2S biology is built. Many of the investigators who now excel in H2S began their scientific journeys studying NO, and over the last decade, they have uncovered significant interactions between these two signaling systems. This makes a keynote on NO biology not only fitting for a conference dedicated to H2S research, but also invaluable — and nobody is better suited to deliver it than Professor Stamler.

An internationally recognized pioneer, Professor Stamler discovered protein S-nitrosylation — the binding of nitric oxide to cysteine residues — a groundbreaking post-translational signaling (PTS) mechanism operating from bacteria to humans. When S-nitrosylation is pathologically altered, it contributes to diseases ranging from heart failure and Alzheimer’s to cancer. He also demonstrated that S-nitrosylation is enzymatically regulated, shaping key physiological processes in the heart, skeletal muscle, and airways. These insights have redefined the role of gaseous messengers in biology, transforming our understanding of NO and redox signaling, and shedding light on the far-reaching impact of post-translational modifications.

In this Keynote Lecture, Professor Stamler will offer a state-of-the-art overview of S-nitrosylation’s mechanisms and effects in mammalian cells and tissues. Meeting participants can discuss with Professor Stamler how S-nitrosylation compares and interacts with other post-translational modifications — such as phosphorylation, oxidation, persulfidation, and cyanylation — giving a uniquely comprehensive perspective on how cells fine-tune their functions via complex posttranslational modifications. We are truly excited to hear from one of the PTS field’s foremost architects and look forward to the new insights his presentation will bring.